Palbociclib Impurity N1 2HCl CAS 2204368-66-9 (free base)
| CAS No. | 2204368-66-9 (free base) |
| Molecular Formula | C24H29N7O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Palbociclib Impurity N1 2HCl (CAS 2204368-66-9 (free base)) is a certified pharmaceutical impurity reference standard with the molecular formula C24H29N7O2HCl and a molecular weight of 484.00 g/mol.
Based on its molecular formula C24H29N7O2HCl, Palbociclib Impurity N1 2HCl contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 484.00 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C24H29N7O2 2*HCl |
| Molecular Weight | 484.00 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 7 |
Related Palbociclib Standards
- Palbociclib Impurity 96 (CAS 1013916-37-4)
- Palbociclib Impurity 25 (CAS 1016636-76-2)
- Palbociclib Impurity 6 (CAS 1023594-49-1)
- Palbociclib Impurity 26 (CAS 1023594-50-4)
- Palbociclib Impurity 2 (CAS 1072-97-5)
- Palbociclib Impurity 32 (CAS 1082876-26-3)
- Palbociclib Impurity 204 (CAS 119285-06-2（free base）)
- Palbociclib Impurity 208 (CAS 120613-50-5)
Recommended Standards
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- Ilaprazole Impurity 83 (CAS CATO-C4X-113083)
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